BORN : 12-JAN-1895 .
BHIMAVARAM, WESTGODAVARI (Dt)
ANDHRA PRADESH, INDIA.
DIED : 9-AUG-1948 ( Aged at 58 )
NATIONALITY : INDIAN.
FIELDS : MEDICINE ( BIO-CHEMIST )
WORKS : 1.PHOSPHOCREATINE
ADENOSINE TRIPHOSPHATE (ATP)
2. SYNTHESIS OF FOLIC ACID
SYNTHESIS OF METHOTREXATE
He conducted clinical trails in the madras Ayurvedic College. Later, he went to Harvard Medical School (HMS) for summer course. He always wanted to study Bio-Chemistry. His brother was died of anaemia while he watched helplessly. He thought that the isolation of the so-called Anti-Pernicious Anaemia Factor (APAF -Vitamin B12) would be a sweet revenge against this dreaded illness.
He discovered ATP substances are the source of energy in muscular activity. It was carried out in MIT in 1925. He developed a deep tank production technique of penicillin to produce in bulk. Folic acid in treatment of tropical sprue. Hetrazan in treatment for filariasis. Aureomycine is frist broad spectrum antibiotic to treat infections. Methotrexate , an anti metabolite - first drug for Cancer chemotherapy treatment.
He researched in liver extract in the treatment of anaemia. He published papers on pantothenic acid,biotin,miscellaneous B complex vitamins,steroids,TB,Trypanosomiasis, Cancer,
He died of atherosclerosis and coronary ischaemia in 1948.